In Ireland, cheese is one of the most exported products. Due to Brexit, it will be most impacted by delays at ports caused by the potential reintroduction of customs or border controls. To predict forthcoming changes and analyze their impact on the cheese supply chain in Ireland, a simulation model was built. To develop the model, the research team used a combination of the agent-based and discrete event modeling approaches along with geographic information system (GIS) included in AnyLogic simulation software.