Fortifying facilities within a supply chain network can mitigate facility failures caused by disruptions. In this study we build an agent-based simulation model to study the r-interdiction median problem with fortification (RIMF), considering two types of facility disruptions: naturally-caused and human-caused disruptions. The objective of this study is to develop a simulation model that analyzes facility disruption and fortification as a repeated Stackelberg competition, where fortification decisions are made anticipating disruptions.