Academic articles

A multi-paradigm, whole system view of health and social care for age-related macular degeneration


This paper presents a hybrid simulation model for the management of an eye condition called age-related macular degeneration, which particularly affects the elderly. The model represents not only the detailed clinical progression of disease in an individual, but also the organization of the hospital clinic in which patients with this condition are treated and the wider environment in which these patients live (and their social care needs, if any, are met). The model permits a ‘whole system’ societal view which captures the interactions between the health and social care systems

Supply chain multi-structural (re)-design


In the framework of supply chain (re)- design (SCD), different structures (functional, organizational, informational, etc.) are (re)- formed. These structures are interrelated and change in their dynamics. How is it possible to avoid structural incoherency and consistency and to achieve comprehensiveness by (re)- designing supply chains? This paper introduces a new approach to simultaneous multi-structural SCD with structure dynamics considerations. We elaborate a new conceptual model and propose new tools for multi-structural SCD – multi-structural macro-states and dynamical alternative multi-graphs. The research approach is theoretically based on the combined application of operations research, agent-based modelling, and control theory. The results show the multi-structural and interdisciplinary treatment allows comprehensive and realistic SCD problem formulation and solution. We emphasize the flexibility of the proposed approach and optimization-supported simulation. The proposed methodology enhances managerial insight into supply chains at the strategic and tactical levels and serves to assist decision-makers in SCD

A hybrid simulation optimization approach for supply chains


The main idea of our approach is to combine discrete-event simulation and exact optimization for supply chain network models. Simulation models are constructed in order to mimic a real system including all necessary stochastic and nonlinear elements. Such simulation models are used as proving grounds for analyzing and improving a real situation on a trial-and-error basis. A traditional optimization method on top of a simulation model has major disadvantages: The optimization method uses the simulation model as a black-box. Information about the structure of the problem is not available and cannot be used for an intelligent optimization strategy