The negative effects of urban freight transports, such as air quality problems, road congestion, and noise emissions lead in many cities to major difficulties. A widely studied measure to reduce these negative effects are Urban Consolidation Centers (UCCs), which aim to bundle freight flows to reduce the number of urban freight transports. However, many projects showed that the additional costs of UCCs often made it unattractive for carriers to participate in such schemes. This paper presents an agent-based simulation to assess the impact of urban access regulations on the cost-attractiveness of UCCs for carriers. A case study inspired by the Frankfurt Rhine-Main area is presented to compare deliveries of a group of carriers with and without a Urban Consolidation Center under various urban access scenarios. The simulation shows that regulations increase the cost-attractiveness of UCCs for carriers to varying degrees while increasing the overall traffic volume.