There has been an increased interest in resilient supplier selection in recent years, much of it focusing on forecasting the disruption probabilities. The results of this study advance our understanding about how and when machine learning and simulation can be combined to create digital supply chain twins, and through these twins improve resilience. The proposed data-driven decision-making model for resilient supplier selection can be further exploited for design of risk mitigation strategies in supply chain disruption management models, redesigning the supplier base or investing in most important and risky suppliers.