In order to cope with the frequent unpredictable changes that may occur in manufacturing systems, and to optimize given performance criteria, the assignment of workers can be decided online in a dynamic manner, whenever the worker is released. Several studies, in the ergonomics literature, have shown that individuals' performances decrease because of their fatigue in work. In manufacturing context, the workers’ fatigue impacts the task durations. Therefore, we propose to solve the online workers assignment problem through a heuristic, which takes this workers' fatigue into consideration, so as to minimize the mean flowtime of jobs.