A simulation model was created to model the traffic flow in the operating room. A key research challenge in operating room design is to create the most efficient layout that supports staff and patient requirements on the day of surgery. The simulation allows comparison of base model designs to future designs using several performance measures. To develop the model, we videotaped multiple surgeries in a set of operating rooms and then coded all activities by location, agent and purpose. Our current analysis compares layouts based on total distance walked by agents, as well as the number of contacts, measured as the number of times agents must change their path to accommodate some other agent or physical constraint in the room. We demonstrate the value and capability of the model by improving traffic flow in the operating room as a result of rotating the bed orientation.