For shuttle trains with a fixed transport capacity which are the dominant operating form in intermodal transport, increasing capacity utilization is of crucial importance due to the low marginal costs of transporting an additional loading unit. Hence, offering rail-based transport services for non-cranable semi-trailers can result in additional earnings for railway companies. However, these earnings have to compensate for the investment costs of the technology. Based on a dynamic investment calculation, this paper presents a simulation model to evaluate the economic profitability of transshipment technologies for non-cranable semi-trailers from the railway company’s perspective. The results depend on the capacity utilization risk faced by the railway company. In particular, if the railway company does not sell all the train capacity to freight forwarders or intermodal operators on a long-term basis, investing in technology for the transshipment of non-cranable semi-trailers can be economically profitable.